STAGE 01 / 06
NasalCart Core
Local retention0
Barrier fidelity0
Mucosal maturity—
Olfactory delivery—
Direct neural—
Systemic route—
BBB-mediated—
Brain-facing—
localolfactorydirect neuralsystemicBBB-mediated
Interactive nasal anatomy + device plume
Sampling ports: choose a port to inspect what the model would quantify at that location.
Deposition map
Device targeting and disease-state parameters dynamically shift the simulated spatial deposition pattern.
Donor variability
Route-resolved mass balance
Normalized conceptual mass balance. The widths visualize how the simulated delivered dose partitions between retained, olfactory/direct, systemic and unaccounted/cleared fractions.
Transport kinetics
localolfactorydirect N2Bsystemic
Virtual histology
These are schematic visualization tiles, not microscopy data. In a real digital twin, this panel could ingest batch-specific imaging and quantitative QC.
Release dashboard
Critical quality attributes & assay package
Architecture benchmark
Conceptual feature comparison only. “Conventional epithelial model” and “animal study” represent broad model classes, not specific commercial products.
Conventional epithelial model
✓ epithelial barrier
✓ mucus/cilia possible
◐ limited structural depth
— cartilage mechanics
— direct neural route
— route-resolved BBB
✓ mucus/cilia possible
◐ limited structural depth
— cartilage mechanics
— direct neural route
— route-resolved BBB
Ex vivo nasal tissue
✓ native architecture
◐ donor variability
◐ limited standardization
◐ finite viability window
— modular route control
— engineered BBB coupling
◐ donor variability
◐ limited standardization
◐ finite viability window
— modular route control
— engineered BBB coupling
Animal intranasal study
✓ whole-organism distribution
◐ species-specific anatomy
◐ lower mechanistic isolation
✓ systemic routes present
◐ difficult route attribution
— human-specific modularity
◐ species-specific anatomy
◐ lower mechanistic isolation
✓ systemic routes present
◐ difficult route attribution
— human-specific modularity
NasalCart platform vision
✓ multicompartment human tissue
✓ mucociliary maturation
✓ device/deposition coupling
✓ cartilage mechanics
✓ olfactory/neural modules
✓ future vascular + BBB route resolution
✓ mucociliary maturation
✓ device/deposition coupling
✓ cartilage mechanics
✓ olfactory/neural modules
✓ future vascular + BBB route resolution
Compounding platform roadmap
Six compounding capability layers—from manufacturable tissue to route-resolved human nasal-interface infrastructure.